Before you start · 2 min
What to really expect
On the same medicine, men lose less weight on average than women. The honest range for men, and why the scale is only one of your numbers.
In one sentence
On average, men lose less weight than women on the same medicine. That's physiology, not weakness, and the scale is only one of the numbers that move.
Most numbers you see online come from trials where most participants were women: about 3 in 4 in STEP 1 with semaglutide, and about 2 in 3 across the first four SURMOUNT trials with tirzepatide.
SELECT, a trial where 72% of participants were men, all aged 45 or older with heart or vascular disease and without diabetes, is a fairer anchor. After two years on weekly semaglutide, men had lost 7.5 percentage points more of their body weight than men on placebo; for women, the gap was 11.1 points. Across several trials, men's advantage over placebo was 2.9 to 6.9 points smaller than women's. These are averages. Your result is yours and doesn't compete with anyone's.
Slower-looking results can wear on motivation. In a large US study, each extra 1% of weight lost went with people being about 3% less likely to stop the medicine, and a 2026 review notes that slower or subtler results can feed self-blame. That's why Hombrio puts other numbers next to the scale: waist, strength, energy and sleep.
For today: pick two numbers besides weight, like your waist and one strength exercise, and record them this week as your starting point. The American Diabetes Association's care standards suggest checking body measurements every 3 months, so you'll have something real to compare.
To take to your appointment
- Besides my weight, what would a good result look like for me?
- How will we tell whether this medicine is working for me?
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